On the Term “Relative Adrenal Insufficiency”—or What Do We Really Measure with Adrenal Stimulation Tests?

Ascorbic acid: what do we really no?

THE HUMAN CUTANEOUS CIRCULATION has emerged as a potential representative vascular bed for investigating mechanisms of microvascular dysfunction in clinical populations. Microvascular dysfunction, including a loss of nitric oxide-dependent vasodilation, is one of the earliest pathological changes associated with cardiovascular disease and is clearly evident in human skin. Several putative mecha...

Superior Capsule Reconstruction: What Do We Know?

The management of irreparable rotator cuff tears remains challenging. Since its introduction by Mihata in 2012, superiorcapsule reconstruction (SCR) has grown in popularity at an astonishingly rapid rate. The aim of this article is to providea comprehensive review of the available literature, in order to highlight what has so far been published on SCR,covering all aspects including biomechanica...

Critical reflection. What do we really mean?

Do we really know what critical reflection means in the context of work-integrated learning, more specifically cooperative education? Critical reflection, in some form, is located within many higher education programmes, including cooperative education and many educators would say this is important for in-depth student learning. It is a form of reflection that is complicated as well as challeng...

Diagnostic and therapeutic challenges for dermatologists: What shall we do when we don’t know what to do?

What shall we do when we have done everything we could for the diagnosis and treatment of a patient, but were not successful? What shall we do when there is no definite treatment for a patient? What shall we do when we have no diagnosis or treatment for a patient? Some useful suggestions are presented here to get rid of these situations.

Do We Know What We Do not Know? A Response to Celine Bonnet